Adjust Information for Interim Monitoring

Group Sequential Design methods can control the Familywise Type I Error (FWER) due to multiple assessments of efficacy. The method used to adjust the sample size of a single stage design to account for multiplicity can also be used to adjust the information level of an information monitored design.

Usage

required_information_sequential(information_single_stage, trial_design)

Arguments

information_single_stage

A numeric scalar containing the information level for an information monitored design with a single efficacy analysis, created using required_information_single_stage()

trial_design

An object of type trialDesignGroupSequential created by rpact::getDesignGroupSequential() containing a group sequential design specification

Value

A scalar information level which accounts for the pre-planned analyses specified in gsd_design_specification

See also

required_information_single_stage() and required_information_mw_single_stage() for obtaining information_single_stage; rpact::getDesignGroupSequential() for obtaining gsd_design_specification.

Examples

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